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Conceptual illustration of DNA with glowing epigenetic marks

CRISPR’s next act: the companies editing the epigenome to treat disease

A handful of start-up firms are testing therapies that target specific epigenetic markers to treat everything from high cholesterol to a rare muscular disorder.

Scientists fight back against far-right plans to restrict academic freedom in Germany

With the far-right Alternative for Germany leading in polls for national and state elections, institutions are facing up to proposed restrictions on academic freedom.

Diana Kwon
News29 Jun 2026
Trump has big AI and quantum ambitions: this scientist’s job is to make them reality

Darío Gil knows that researchers are sceptical of the massive US artificial-intelligence push — he’s asking them to keep an open mind.

Elizabeth Gibney
News29 Jun 2026
Disparate privacy risks from medical AI

AI models for medical diagnostics are vulnerable to membership inference attacks.

Moritz A. Knolle
Martin J. Menten
Georgios Kaissis
ArticleOpen Access24 Jun 2026
Daily briefing: Humans and great apes giggle in the same rhythms

The findings hint that vocal motor control might have evolved from a shared ancestor. Plus, sea turtles’ navigation skills are only so-so and what’s next for the International Space Station.

Jacob Smith
Nature Briefing25 Jun 2026
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Trump has big AI and quantum ambitions: this scientist’s job is to make them reality

Darío Gil knows that researchers are sceptical of the massive US artificial-intelligence push — he’s asking them to keep an open mind.

Elizabeth Gibney

News29 Jun 2026
Scientists fight back against far-right plans to restrict academic freedom in Germany
Diana Kwon

News29 Jun 2026
The poetry of twilight and the awe-inspiring magic of eclipses: Books in brief
Andrew Robinson

Book Review26 Jun 2026
I study World Cup penalty shoot-outs: they say a lot about the psychology of performance under pressure
Geir Jordet

World View26 Jun 2026
CRISPR’s next act: the companies editing the epigenome to treat disease
Roxanne Khamsi

News Feature26 Jun 2026
Inside the new political screening that’s stalling NIH grants
Max Kozlov

News26 Jun 2026
Can you terraform Mars? Try Nature’s game
Alexandra Witze

News Feature25 Jun 2026

Latest Reviews & Analysis

- How long-term dietary cholesterol can slow down its own clearance by liver cells
  
  Cholesterol carried by low-density lipoprotein (LDL) drives heart disease and is cleared by liver cells expressing the receptor LDLR. A cell-signalling mechanism has been discovered through which high cholesterol promotes the enzyme-mediated degradation of LDLR. Blocking this enzyme restores LDLR levels in liver cells, suggesting a new strategy for treating high cholesterol.
  
  Research Briefing25 Jun 2026
- Electric fields probe the symmetry of the ‘heavy hydrogen’ nucleus
  
  The response of the nucleus of a deuterium atom to electric fields shows no evidence of asymmetry, which is consistent with conventional theories of particle physics.
  
  Steven Hoekstra
  
  News & Views25 Jun 2026
- Laser light switches on heat flow in ultra-thin structures
  
  A temperature difference of more than 100 kelvin can be created between stacked layers of 2D material by irradiating them with laser light.
  
  Steven P. Hepplestone
  Robert J. Hicken
  
  News & Views24 Jun 2026
- Genomic insights into the population dynamics and demise of Neanderthals
  
  A surge of genetic data from the skeletal remains of Neanderthals disproves some assumptions and generates fresh questions about these ancient hominins.
  
  Carles Lalueza-Fox
  
  News & Views24 Jun 2026
- A hidden predictor of sudden cardiac death uncovered by deep learning
  
  A machine-learning model trained on thousands of electrocardiogram recordings identifies a previously unrecognized group of at-risk people.
  
  Changxin Lai
  
  News & Views24 Jun 2026
- ‘Megacluster’ of genes enables bacteria to make potent antibiotic mixture
  
  Steven T. Rutherford
  
  News & Views24 Jun 2026
- Crude oil turns cheap porous membrane into a sieve to refine itself without heat
  
  Research Briefing24 Jun 2026
- Long-sought chemical inhibitors of β-arrestin proteins
  
  Research Briefing24 Jun 2026
- A global map of seagrass ecosystems
  
  Carlos M. Duarte
  Dorte Krause-Jensen
  
  News & Views24 Jun 2026

Latest Research articles

Ligand-enabled distal desaturative lactonization of aliphatic acids

Tanay Pal
Md Saimuddin Sk
Debabrata Maiti
Article25 Jun 2026
Base editing reveals an essential role for NANOG in human embryogenesis

Oliver J. Bower
Ana E. R. Orsi
Kathy K. Niakan
Article25 Jun 2026
Role of methanesulfonic acid in atmospheric particle nucleation and growth

Rima Baalbaki
Jiali Shen
Xu-Cheng He
Article24 Jun 2026
The mutational landscape of STING-induced immunity

A massively parallel assay systematically charts the sequence-function landscape of the STING signalling protein, and the findings define molecular principles that tune STING activity and show its functional potential across immune contexts.

Bing Zhang
Pengbiao Xu
Andrea Ablasser
ArticleOpen Access24 Jun 2026
Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover

Chronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing cholesterol clearance, whereas CTSA inhibition restores LDLR function and may offer a therapeutic strategy for cardiovascular disease.

Xue Feng
Shuo Zhang
Alan R. Saltiel
Article24 Jun 2026

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CRISPR’s next act: the companies editing the epigenome to treat disease

Scientists fight back against far-right plans to restrict academic freedom in Germany

Trump has big AI and quantum ambitions: this scientist’s job is to make them reality

Disparate privacy risks from medical AI

Daily briefing: Humans and great apes giggle in the same rhythms

News & Comment

Trump has big AI and quantum ambitions: this scientist’s job is to make them reality

Scientists fight back against far-right plans to restrict academic freedom in Germany

The poetry of twilight and the awe-inspiring magic of eclipses: Books in brief

I study World Cup penalty shoot-outs: they say a lot about the psychology of performance under pressure

CRISPR’s next act: the companies editing the epigenome to treat disease

Inside the new political screening that’s stalling NIH grants

Can you terraform Mars? Try Nature’s game

Latest Reviews & Analysis

How long-term dietary cholesterol can slow down its own clearance by liver cells

Electric fields probe the symmetry of the ‘heavy hydrogen’ nucleus

Laser light switches on heat flow in ultra-thin structures

Genomic insights into the population dynamics and demise of Neanderthals

A hidden predictor of sudden cardiac death uncovered by deep learning

‘Megacluster’ of genes enables bacteria to make potent antibiotic mixture

Crude oil turns cheap porous membrane into a sieve to refine itself without heat

Long-sought chemical inhibitors of β-arrestin proteins

A global map of seagrass ecosystems

Latest Research articles

Ligand-enabled distal desaturative lactonization of aliphatic acids

Base editing reveals an essential role for NANOG in human embryogenesis

Role of methanesulfonic acid in atmospheric particle nucleation and growth

The mutational landscape of STING-induced immunity

Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover

Collections

Chemistry

Trending - Altmetric

Science jobs

Faculty Positions at Institute of Physics (IOP), Chinese Academy of Sciences

Global Talent Recruitment Announcement of the College of Engineering, HZAU

Early-Career Group Leader Opportunities: Xuemin Investigator Program

Chief Magazine Editor

Interim Associate or Senior Editor, Nature Energy

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