Nature

Novel CRISPR therapy is poised to gain first FDA approval to alter genes inside the body

Earlier CRISPR treatments require removal of a participant’s cells, a complex and costly approach.

This AI ‘mechanic’ can peer inside the black box of other neural networks

Being able to target and debug systems could improve artificial-intelligence safety and utility.

Elizabeth Gibney
News13 Nov 2026
Massive atlas of brain region linked to a host of diseases is the most detailed yet

A global team profiled nearly 26 million brain cells from the basal ganglia to build a cross-species reference database that will help to understand conditions from Parkinson’s disease to addiction.

Miryam Naddaf
News12 Nov 2026
Severe drought and warming increase the extinction risk of cacti

Severe drought and warming will substantially increase the loss of suitable climatic area for cactus species.

Michiel D. Pillet
Brian S. Maitner
Brian J. Enquist
Article11 Nov 2026
Daily briefing: Should old, bad science be culled from the literature?

AI tools that summarize scientific literature are picking up decades-old flawed papers — should they be retracted? Plus, the first image of a black hole holds up to scrutiny and how the Artemis II mission might have disrupted GPS.

Flora Graham
Nature Briefing11 Nov 2026
- Contents
- Subscribe
Current Issue12 Nov 2026

News & Comment

Number of international students arriving in US plunges — worrying scientists

Declines in students from China and India are driving the trend, which researchers say could slow the progress of US science.

Dan Garisto

News13 Nov 2026
This AI ‘mechanic’ can peer inside the black box of other neural networks
Elizabeth Gibney

News13 Nov 2026
Who needs sex? Kelp reproduce asexually when no mate is nearby
Giorgia Guglielmi

News12 Nov 2026
Record-breaking Ebola outbreak: phone data reconstruct first weeks of spread
Mohana Basu

News12 Nov 2026
Massive atlas of brain region linked to a host of diseases is the most detailed yet
Miryam Naddaf

News12 Nov 2026
RSV vaccines slash infections: data show jabs’ staggering success against dangerous virus
Liam Drew

News12 Nov 2026
Novel CRISPR therapy is poised to gain first FDA approval to alter genes inside the body
Heidi Ledford

News12 Nov 2026

Latest Reviews & Analysis

- Getting a grasp on the global wildlife trade
  
  A study reports that about 107,000 species are traded worldwide, legally or illegally — more than double a previous estimate.
  
  Mary Abraham
  
  News & Views11 Nov 2026
- Salty grains in Saturn’s outermost ring formed from the slow freeze of plumes from the moon Enceladus
  
  One of Saturn’s rings consists of a diverse population of icy and rocky grains, each with a distinct composition. How this came about might now have an explanation.
  
  Kevin P. Hand
  
  News & Views11 Nov 2026
- Cacti are severely threatened by drought in a warming world
  
  Forecasts of the effects that climate change will have on biodiversity typically rely on long-term climate averages while excluding extreme events. Projections that include severe drought predict that a majority of the 993 cactus species assessed will see large losses of suitable climatic area: more than 25% of species could lose at least 80% of it by 2100.
  
  Research Briefing11 Nov 2026
- Extraordinary materials shaped by the principles of complex networks
  
  Network science has inspired the design of materials that spread out their deformation when a force is applied, have tunable stiffness and can control vibrational waves.
  
  Marco Paggi
  
  News & Views11 Nov 2026
- Proteins that form the nuclear pore barrier move like liquids
  
  Nuclear pores control molecular traffic into and out of the cell nucleus. Measurements in living cells, together with molecular-dynamics simulations, show that flexible protein chains that form the selectivity barriers of nuclear pores are highly mobile, and that a sugar modification and the carrier protein importin-β help to preserve this dynamic state.
  
  Research Briefing11 Nov 2026
- Earth’s early history told by 3.9-billion-year-old rocks from northern China
  
  Research Briefing11 Nov 2026
- Proposed approach for diagnosing obesity outperforms old method
  
  Clinical Briefing11 Nov 2026
- Personal incentives for public officials drove a drop in China’s fertility
  
  Jia Yu
  
  News & Views11 Nov 2026
- A practically perfect plesiosaur
  
  News & Views10 Nov 2026

Latest Research articles

Efficient catalyst-controlled C–H arylation of arenes

Minhao Zhang
Elisa González-Fernández
Ilija Čorić
Article11 Nov 2026
Human replisomes direct a dedicated leading-strand primase for fork restart

Structural and biochemical studies show that the CMG helicase directly recruits PRIMPOL for leading-strand repriming, enabling replication fork restart and limiting post-replicative DNA gaps.

Cristian Polo Rivera
Johann J. Roske
Joseph T. P. Yeeles
ArticleOpen Access11 Nov 2026
Bureaucratic incentives shaped effectiveness of the one-child policy in China

Stronger bureaucratic incentives under China’s one vote veto policy intensified enforcement of the one-child policy, accounting for nearly half of China’s fertility decline during the 1990s.

Lingsheng Meng
Hanmo Yang
Hongbin Li
ArticleOpen Access11 Nov 2026
Validation of clinical and preclinical obesity across global cohorts

A large-scale data analysis assesses the Lancet Commission’s proposed diagnostic framework for obesity, finding that this framework, in which BMI is combined with other criteria, such as waist circumference and organ function, is more useful than classifications based on BMI alone.

An Pan
Shengping Yang
Francesco Rubino
ArticleOpen Access11 Nov 2026
UNC13A splice correction rescues synaptic dysfunction induced by TDP-43 loss

TDP-43 loss induces a predegenerative state in which neurons remain structurally intact and suffer a substantial breakdown in synaptic communication; a therapeutic strategy is found that corrects UNC13A cryptic splicing by using splice-switching antisense oligonucleotides.

Matthew J. Keuss
Peter Harley
Pietro Fratta
ArticleOpen Access11 Nov 2026

Collections

Elderly-looking man with cap and scarf pedals a bicycle through what at first appears to be a pastoral landscape but that on closer inspection is the interior of a human brain, with neurons appearing as various flora.

Parkinson’s disease

Improved therapies and fresh biological insights are raising hopes for effectively managing this neurodegenerative disorder.

Nature Outlook 04 Nov 2026

Trending - Altmetric

Science jobs

Tenure-Track Faculty Positions at the Institute of Fluid Science, Tohoku University

Tohoku Univ. IFS seeks researchers in science & engineering to advance fluid science, pioneer interdisciplinary areas, or address societal challenges.

Japan (JP)

Tohoku University
Four PhD fellowships in AI-driven plant biology - University of Copenhagen

Four PhD positions (NNF and MSCA) on knowledge graphs, single-cell stress networks and plant metabolic pathways. Deadline 31 Jan 2027.

Frederiksberg Campus, University of Copenhagen, Denmark

University of Copenhagen, Department of Plant and Environmental Sciences
Strategic Scientist, Outstanding Youg Investigator, and Postdoctoral Positions at CIBCAS

CIB invites distinguished Strategic Scientist, Outstanding Young Investigator, and Postdoctoral Research Fellow.

Chengdu, Sichuan (CN)

Chengdu Institute of Biology, Chinese Academy of Sciences
State Key Laboratory of Quantitative Synthetic Biology Global Talent Wanted

Applicants should meet the requirements for the National Science Fund for Excellent Young Scholars (overseas), please refer to the Part IV for details

Shenzhen, Guangdong (CN)

The State Key Laboratory of Quantitative Synthetic Biology
Assistant Professor, Tenure Track, CHOP Division of Hematology

Perelman School of Medicine at the University of Pennsylvania seek candidates for an Assistant Professor position in the tenure track.

Philadelphia, Pennsylvania (US)

University of Pennsylvania

Novel CRISPR therapy is poised to gain first FDA approval to alter genes inside the body

This AI ‘mechanic’ can peer inside the black box of other neural networks

Massive atlas of brain region linked to a host of diseases is the most detailed yet

Severe drought and warming increase the extinction risk of cacti

Daily briefing: Should old, bad science be culled from the literature?

News & Comment

Number of international students arriving in US plunges — worrying scientists

This AI ‘mechanic’ can peer inside the black box of other neural networks

Who needs sex? Kelp reproduce asexually when no mate is nearby

Record-breaking Ebola outbreak: phone data reconstruct first weeks of spread

Massive atlas of brain region linked to a host of diseases is the most detailed yet

RSV vaccines slash infections: data show jabs’ staggering success against dangerous virus

Novel CRISPR therapy is poised to gain first FDA approval to alter genes inside the body

Latest Reviews & Analysis

Getting a grasp on the global wildlife trade

Salty grains in Saturn’s outermost ring formed from the slow freeze of plumes from the moon Enceladus

Cacti are severely threatened by drought in a warming world

Extraordinary materials shaped by the principles of complex networks

Proteins that form the nuclear pore barrier move like liquids

Earth’s early history told by 3.9-billion-year-old rocks from northern China

Proposed approach for diagnosing obesity outperforms old method

Personal incentives for public officials drove a drop in China’s fertility

A practically perfect plesiosaur

Latest Research articles

Efficient catalyst-controlled C–H arylation of arenes

Human replisomes direct a dedicated leading-strand primase for fork restart

Bureaucratic incentives shaped effectiveness of the one-child policy in China

Validation of clinical and preclinical obesity across global cohorts

UNC13A splice correction rescues synaptic dysfunction induced by TDP-43 loss

Collections

Parkinson’s disease

Trending - Altmetric

Science jobs

Tenure-Track Faculty Positions at the Institute of Fluid Science, Tohoku University

Four PhD fellowships in AI-driven plant biology - University of Copenhagen

Strategic Scientist, Outstanding Youg Investigator, and Postdoctoral Positions at CIBCAS

State Key Laboratory of Quantitative Synthetic Biology Global Talent Wanted

Assistant Professor, Tenure Track, CHOP Division of Hematology

Search

Quick links

Featured Content

Advertisement

Trending - Altmetric

Nearly half of reef-building corals face elevated relative risk of extinction

Validation of clinical and preclinical obesity across global cohorts

How academic freedom is changing around the world — by the numbers

RSV vaccines slash infections: data show jabs’ staggering success against dangerous virus

Search

Quick links